In this talk, Prof. Jiming Liu will share some of their stories in a journey of translating exciting computer science research into socially impactful solutions in infectious disease control and prevention, e.g., in combating the outbreaks of malaria, swine flu, and COVID-19. He will discuss their ongoing interdisciplinary efforts in developing and deploying Data Science and AI technologies for addressing some of the most pressing needs in global health, while envisioning grand computational and epidemiological challenges, as well as opportunities, ahead.