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Lanthanide Toolbox 鑭系元素工具箱

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DEPARTMENT : Department of Chemistry

PRODUCER : Knowledge Transfer Office
PROJECT YEAR : 2017
LENGTH : 4 min.
ACCESS : Open to all
SUMMARY : The “Lanthanide Toolbox” invented by Dr Gary Wong is a new medical imaging reagent that can detect Joubert syndrome and other genetic disorders that come under an emerging class of disorders called Ciliopathies.

There are a few current medical imaging reagents, e.g. GFP-ARL13B which play crucial roles in diagnostic, pharmaceuticals, biotechnology medical and life science industry sectors. We have invented a new potent medical imaging reagent – Lanthanide Toolbox. While GFP-ARL13B can be used for Joubert-syndrome* diagnosis (a rare genetic disorder that affects the cerebellum), there are many drawbacks such as time consuming, expensive and stringent requirements for running a test and storage.

“Lanthanide Toolbox” for primary cilium (PC) imaging would solve the above problems that it is able to provide a test result in a mere six hours at a fraction of the cost of the current technology through a simpler process in an environment closer to normal conditions and can achieve 100% accuracy. Furthermore, identifying primary cilium marker is a breakthrough. It is crucial for cancer formation detection.

黃嘉良博士的「鑭系元素工具箱」是新發明的醫學造影試劑,可用於檢測Joubert綜合症和新近出現稱為「纖毛病變」的一類遺傳疾病。

現時醫學成像試劑為數不多,如GFP-ARL13B,在診斷、藥物治療、生物科技及生命科學行業上擔起重要的角色。我們研發了新 的成像試劑-「鑭系元素工具箱」。一般人利用GFP-ARL13B檢測茹貝爾綜合症*(家族性小腦蚓部發育不全)。然而,它有一些缺點,包括檢測耗時、高昂成本、嚴格的測試和存儲等要求。

本新發明「鑭系元素工具箱」能應用於初級纖毛成像,可有效改善以上缺點。這種新的初級纖毛標記物能夠在六小時內,在接近正常條件的環境中通過比當前技術更簡單的方法提供測試結果,成本更大幅低,而且準確度達百份之一百。此外,初級纖毛標記物的研發更是一大突破,在檢測癌細胞形成有著重大意義。  
LINK : http://kto.hkbu.edu.hk/



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