A Modified Huang-Lian-Jie-Du-Tang for Treating Alzheimer's Disease
School of Chinese Medicine
Professor Li Min
PROJECT YEAR :
2014 - current
Open to all
Traditional Chinese Medicine (TCM) has a long history and there are so many prescriptions and applications. TCM has been familiar to people, for example, Huanglianjiedu Tang (HLJDT, 黃連解毒湯) firstly mentioned in "Waitai Miyao” in the Tang Dynasty, consists of Rhizoma Coptidis (黃連), Cortex Phellodendri (黃柏), Radix Scutellariae (黄芩) and Fructus Gardenia (梔子).
It is commonly used to treat heat and remove toxins, and is adopted by the medical professionals in Japan. Recent literature shows that HLJDT has significant effects in anti-inflammation, anti-cerebral ischemia, anti-tumor, reducing blood lipids, mitigating liver damage, etc. Its clinical studies of the last century mainly focus in the fields of cerebrovascular disease and mental illness.
In the 21st century, HLJDT has been used to treat many different kinds of diseases. Prof. Li Min from the School of Chinese Medicine of Hong Kong Baptist University and her research team found that the modified HLJDT promotes the degradation of amyloid β-peptide (Aβ) and tau aggregates for both in-vitro and in-vivo tests. It can also pass through the blood-brain barrier and clear the accumulation of these proteins, which is the major root cause of Alzheimer's disease. The modified formulation invented by Prof. Li’s team gives hope to the patients with Alzheimer’s disease.
This innovative research has filed patents in China and Hong Kong and granted in U.S. After removing a particular herb in HLJDT, this modified formulation has given more significant therapeutic and pharmacological effects in Alzheimer's disease with extremely low side effects.
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